Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts
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چکیده
منابع مشابه
Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts.
DNA mismatch repair (MMR) deficiency leads to an increased mutation frequency and a predisposition to neoplasia. 'Knockout' mice deficient in the MMR proteins Msh2 and Pms2 crossed with mutation detection reporter (supF, lacI and cII) transgenic mice have been used to facilitate a comparison of the changes in mutation frequency and spectra. We find that the mutation frequency was consistently h...
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Deficiencies in DNA mismatch repair (MMR) result in increased mutation rates and cancer risk in both humans and mice. Mouse strains homozygous for knockouts of either the Pms2 or Mlh1 MMR gene develop cancer but exhibit very different tumor spectra; only Mlh1(-/-) animals develop intestinal tumors. We carried out a detailed study of the microsatellite mutation spectra in each knockout strain. F...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2000
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/21.7.1291